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In order to conserve the limited bandwidth available .iso images are not downloadable from mirror.centos.org

The following mirrors should have the ISO images available:

http://mirrors.arsc.edu/centos/5.10/isos/x86_64/
ftp://mirror.nandomedia.com/pub/CentOS/5.10/isos/x86_64/
http://mirror.metrocast.net/centos/5.10/isos/x86_64/
http://mirrors.maine.edu/CentOS/5.10/isos/x86_64/
http://mirrors.advancedhosters.com/centos/5.10/isos/x86_64/
ftp://ftp.ussg.iu.edu/linux/centos/5.10/isos/x86_64/
http://centos.clearvoiceone.com/5.10/isos/x86_64/
http://mirror.chpc.utah.edu/pub/centos/5.10/isos/x86_64/
http://ftp.osuosl.org/pub/centos/5.10/isos/x86_64/
http://centos.mirror.nac.net/5.10/isos/x86_64/
http://mirrors.lga7.us.voxel.net/centos/5.10/isos/x86_64/
http://mirrors.usc.edu/pub/linux/distributions/centos/5.10/isos/x86_64/
http://mirrors.xmission.com/centos/5.10/isos/x86_64/
http://lug.mtu.edu/centos/5.10/isos/x86_64/
http://centos.corenetworks.net/5.10/isos/x86_64/
http://mirror.san.fastserv.com/pub/linux/centos/5.10/isos/x86_64/
http://mirror.millry.co/CentOS/5.10/isos/x86_64/

Mirrors Verified Fri Aug 1 09:32:12 2014 UTC

Or use bittorrent to download the .torrent files provided.

Bittorrent is a peer to peer download system described at http://bittorrent.com/ and there are many clients available.

These include (in no particular order of preference): utorrent, vuze (Azureus), BitTorrent, Deluge, ctorrent, ktorrent, rtorrent and transmission.

Packaged copies of various torrent clients for CentOS can be found in the repositories listed in the following wiki article : http://wiki.centos.org/AdditionalResources/Repositories